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目的:探讨伴随月经紊乱的不孕症患者卵巢储备功能状态。方法:回顾性分析2009年09月至2011年8月在南方医科大学附属小榄医院就诊的251例育龄期妇女的临床资料,其中月经正常对照组(60例)、月经正常不孕组(103例)、月经紊乱不孕组(88例);同时按月经紊乱类型将88例月经紊乱不孕症患者分为经量增多组(8例)、经量减少组(19例)、周期延长组(30例)、周期缩短组(31例)。比较患者卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E_2)及FSH/LH比值等指标。结果:月经紊乱不孕组患者的FSH值、LH值、FSH/LH比值均明显大于月经正常不孕组(P<0.05)。月经正常对照组与月经紊乱不孕组患者的血清FSH值、LH值、FSH/LH比值比较,差异有统计学意义(P<0.05)。月经紊乱不孕组中经量减少组、周期延长组、周期缩短组患者年龄、LH值、FSH/LH比值、自然流产次数比较,差异有统计学意义(P<0.05)。结论:伴随月经紊乱的不孕症患者的卵巢储备功能明显下降,其中以月经周期缩短者最严重。
Objective: To investigate the status of ovarian reserve in infertile patients with menstrual disorders. Methods: Clinical data of 251 women of childbearing age who were treated in Xiaolan Hospital Affiliated to Southern Medical University from September 2009 to August 2011 were retrospectively analyzed. Among them, the normal menstruation group (60 cases), the normal menstruation group (103 cases) (N = 88) .Meanwhile, according to the types of menstrual disorders, 88 patients with menstrual disorders and infertility were divided into three groups: the increased volume group (n = 8), the reduced volume group (n = 19) (30 cases), shortened group (31 cases). The indexes of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and FSH / LH ratio were compared. Results: FSH value, LH value, FSH / LH ratio of infertile patients with menstrual disorders were significantly higher than those of normal infertility patients (P <0.05). There were significant differences in serum FSH, LH and FSH / LH between normal control group and menstrual disturbance and infertility group (P <0.05). The age, LH value, FSH / LH ratio and the number of spontaneous abortion in menstruation disorder infertility group had significant difference (P <0.05). Conclusion: The infertility patients with menstrual disorders have significantly decreased ovarian reserve, of which the shortest menstrual cycle is the most serious.