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目的探讨诺和锐30强化治疗对初诊2型糖尿病患者血糖及胰岛功能的影响。方法对40例初诊2型糖尿病患者进行2周的诺和锐30治疗,分析治疗前后空腹血糖(FPG)及餐后2h血糖(2hPG)、糖化血红蛋白(HbA lc)、静脉葡萄糖耐量试验第一时项胰岛素及C肽分泌和胰岛素及C肽曲线下面积、胰岛素抵抗指数、胰岛素分泌指数、胰岛素敏感指数、空腹胰岛素(FINS)与FPG比值。结果诺和锐30治疗后,FPG、2hPG、HbA lc、胰岛素抵抗指数均较治疗前明显下降(P<0.01);空腹及第一时项胰岛素和C肽的分泌、胰岛素及C肽曲线下面积、FINS与FPG比值、胰岛素分泌指数、胰岛素敏感指数均较治疗前明显升高(P<0.01)。结论诺和锐30强化治疗能显著改善初诊2型糖尿病患者的血糖及胰岛功能。
Objective To investigate the effects of Novo-Rui-30 treatment on blood glucose and islet function in newly diagnosed type 2 diabetic patients. Methods Forty newly diagnosed patients with type 2 diabetes were treated with Novo-Rui-Rui-30 for two weeks. The levels of fasting blood glucose (FPG) and postprandial 2-hour blood glucose (2hPG), HbA1c and venous glucose tolerance test Insulin and C-peptide secretion and area under the curve of insulin and C-peptide, insulin resistance index, insulin secretion index, insulin sensitivity index, fasting insulin (FINS) and FPG ratio. Results After treatment with Nuo-Rui-Rui 30, the FPG, 2hPG, HbA1c and insulin resistance index decreased significantly (P <0.01); the fasting and first insulin and C peptide secretion, the area under the curve of insulin and C-peptide , FINS and FPG ratio, insulin secretion index, insulin sensitivity index were significantly higher than before treatment (P <0.01). Conclusion Nuo-Rui-Rui-30 intensive treatment can significantly improve the newly diagnosed type 2 diabetes patients with blood glucose and pancreatic islet function.