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目的探讨不同剂量的糖皮质激素联合N-乙酰半胱氨酸治疗特发性肺纤维化的效果。方法选择2009年8月～2012年8月符合国际呼吸协会诊断的特发性肺纤维化患者56例,随机分为两组,均用糖皮质激素+N-乙酰半胱氨酸治疗,观察组和对照组的糖皮质激素用量分别是800μg/d、200μg/d,比较治疗前后肺功能指标变化、临床症状改善时间、不良反应和总有效率。结果观察组的肺功能指标改善、症状改善时间、不良反应率和治疗总有效率优于对照组,差异有统计学意义。结论治疗特发性肺纤维化疾病,在短期内应用大剂量糖皮质激素联合N-乙酰半胱氨酸治疗更有效。
Objective To investigate the effect of different doses of glucocorticoids combined with N-acetylcysteine in the treatment of idiopathic pulmonary fibrosis. Methods Fifty-six patients with Idiopathic Pulmonary Fibrosis diagnosed by the International Association of Respiratory Society from August 2009 to August 2012 were randomly divided into two groups, all treated with glucocorticoid + N-acetylcysteine. The observation group And control group were 800μg / d, 200μg / d, before and after treatment to compare changes in lung function, clinical symptoms improved time, adverse reactions and total effective rate. Results The observation group improved lung function, symptom improvement time, adverse reaction rate and total effective rate was better than the control group, the difference was statistically significant. Conclusion The treatment of idiopathic pulmonary fibrosis in the short term with high-dose glucocorticoid combined with N-acetylcysteine is more effective.