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目的:研究细胞周期相关蛋白P53和核蛋白抗原Ki67在口腔鳞癌组织中的表达及其与预后的相关性,寻找预后判断的有效生物标志物。方法:用免疫组织化学EnVision染色法的方法检测随访资料完整的132例口腔鳞癌患者术后石蜡切片中P53、Ki67蛋白的表达,研究口腔鳞癌组织中P53、Ki67与病理特征的相关性及口腔鳞癌预后的相关性。结果:132例口腔鳞癌标本蛋白检测和统计分析结果表明,P53和Ki-67蛋白在口腔鳞癌中的高表达与患者细胞分化程度,肿瘤T分期和肿瘤原发灶有关(P<0.05);P53蛋白的表达水平与口腔鳞癌术后生存率呈显著的相关性(P<0.05);Ki67蛋白的表达水平与口腔鳞癌术后生存时间并无显著的相关性。结论:口腔鳞癌患者癌组织标本的P53表达水平与预后呈正相关,P53有望成为口腔鳞癌预后判断的间接性生物标志物。
Objective: To study the expression of cell cycle related protein P53 and nuclear protein antigen Ki67 in oral squamous cell carcinoma and its correlation with prognosis, in order to find an effective biomarker for prognosis. Methods: The immunohistochemical EnVision staining method was used to detect the expression of P53 and Ki67 in paraffin sections of 132 patients with oral squamous cell carcinoma with complete follow-up data. The correlation between P53 and Ki67 and the pathological features of oral squamous cell carcinoma was analyzed. Correlation of prognosis of oral squamous cell. Results: The detection and statistical analysis of 132 cases of oral squamous cell carcinoma showed that the overexpression of P53 and Ki-67 in oral squamous cell carcinoma correlated with cell differentiation degree, tumor T stage and primary tumor (P <0.05) There was a significant correlation between the expression of P53 protein and the postoperative survival rate of oral squamous cell carcinoma (P <0.05). The expression of Ki67 protein had no significant correlation with the postoperative survival time of oral squamous cell carcinoma. Conclusion: The expression of P53 in oral squamous cell carcinoma is positively correlated with prognosis. P53 is expected to be an indirect biomarker for the prognosis of oral squamous cell carcinoma.