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解热镇痛药扑热息痛(acetaminophen)在治疗剂量下为非毒性物质,但在超剂量下会引起严重的肝脏毒性,表现为进行性的谷胱甘肽(是对抗化学致肝毒的重要生物活性分子)下降衰竭,抑制谷胱甘肽的生物合成,肝细胞坏死,在某些情况下还会导致脂质的过氧化作用。水飞蓟素二琥珀酸氢盐(silybin dihe-misuccinate)为一水溶性的黄酮类化合物。曾有报道认为它对由毒伞素(phalioidin),α-鹅膏菌素(α-amanitin),镨(Pr, Praseodymium),四氯化碳和乙基硫氨酸(ethionine)诱导的肝
Acetaminophen, an antipyretic analgesic, is non-toxic at therapeutic doses but causes serious hepatic toxicity at overdose, manifested as progressive glutathione, an important biological activity against chemical hepatotoxicity Molecules) decline failure, inhibit glutathione biosynthesis, liver cell necrosis, and in some cases can lead to lipid peroxidation. Silybin dihe-misuccinate is a water-soluble flavonoid. It has been reported that it exerts a protective effect on the liver induced by phalioidin, a-amanitin, Pr, Praseodymium, carbon tetrachloride and ethionine