IL-2可诱导很多细胞因子,包括TNF-α、IFN-γ,IFN-αGM-CSF 的合成和分泌,它们在LAK 调节中起重要作用。IL-4是由激活的T 细胞分泌的一种20KD 的糖蛋白,它对B 细胞、T 细胞、NK 细胞、肥大细胞和单核细胞均有不同程度的影响。IL-4对IL-2刺激的人脾细胞、胸腺细胞和PBL产生的LAK 细胞有很强的抑制作用。本文证明IL-4能抑制PBMC 在IL-2诱导下产生TNF-α、IFN-γ,而外源性TNF-α、IFN-γ能部分逆转这种抑制作用。 IL-2 induces the synthesis and secretion of many cytokines, including TNF-α, IFN-γ, IFN-α GM-CSF, which play an important role in LAK regulation. IL-4 is a 20KD glycoprotein secreted by activated T cells that affects B cells, T cells, NK cells, mast cells and monocytes to varying degrees. IL-4 has a strong inhibitory effect on IL-2 stimulated human spleen cells, thymocytes and PBL-producing LAK cells. This article demonstrated that IL-4 can inhibit the production of TNF-α and IFN-γ in PBMC induced by IL-2, while exogenous TNF-α and IFN-γ partially reversed this inhibition.