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促性腺激素释放激素(Gonadotropin-releasing hormone,GnRH)是继促甲状腺素释放激素fTRH)之后从下丘脑中发现的促腺垂体的第二个多肽激素。1971年Schally首先从猪的下丘脑中分离出并阐明该物质由9种氨基酸组成的十肽,同年人工合成。目前为止,已人工合成约2000余种类似物。实验室和临床发现,由于给药方式不同和疗程不一,可引起性腺轴系的正反双向反应,又称异相作用(Paradoxical action),人们正利用GnRH的异相作用,探索将它的类似物发展为抗生育药物。
Gonadotropin-releasing hormone (GnRH) is the second pro-pituitary hormone found in the hypothalamus following the thyrotropin-releasing hormone fTRH. In 1971, Schally first isolated from the hypothalamus of pigs and elucidated that the substance is composed of nine kinds of amino acids decapeptide, the same year artificial synthesis. So far, more than 2,000 analogs have been artificially synthesized. Laboratory and clinical findings, due to different modes of administration and treatment varies, can cause positive and negative two-way response of the gonadal axis system, also known as the paradoxical action (Paradoxical action), people are using the heterogeneous effects of GnRH to explore its Analogs develop into anti-fertility drugs.