论文部分内容阅读
目的比较2型糖尿病患者口服降糖药物失效后启用基础胰岛素与预混胰岛素的安全性和有效性。方法将2012年1月至2014年2月200例口服药物失效2型糖尿病患者随机分为基础胰岛素组(基础组)及预混人胰岛素组(预混组),基础胰岛素组继续继口服降糖药物并加用甘精胰岛素(来得时),根据血糖情况调整胰岛素剂量及口服药物;预混组停用口服药物,改为精蛋白生物合成人胰岛素[预混30R(诺和灵30R)]治疗。连续治疗24周并定期随访,观察两组治疗的安全性和有效性。结果治疗24周后,与预混组比较,基础组的依从性明显高于预混组(87.0%vs 75.0%,P<0.05);有症状、有依据性低血糖事件,基础组明显低于预混组(9.2%vs 20.0%,P<0.05);基础组的糖化血红蛋白(Hb A1c)达标率高于预混组(81.6%vs 66.7%,P<0.05);预混组的体重大于基础组,但差异无统计学意义(P>0.05);基础组的Hb A1c明显低于于预混组,但差异无统计学意义(P>0.05);两组均无严重不良事件发生。结论基础组与预混组均能有效降低Hb A1c,但基础组的治疗依从性及Hb A1c达标率明显高于预混组,低血糖事件发生率明显低于预混组。
Objective To compare the safety and efficacy of basal insulin and premixed insulin after oral administration of antidiabetic drugs in type 2 diabetic patients. Methods From January 2012 to February 2014,200 cases of oral drug-induced type 2 diabetes mellitus were randomly divided into basal insulin group and pre-mixed insulin group (premixed group). The basal insulin group continued to be oral hypoglycemic Drugs and insulin plus glargine (when), according to the blood glucose to adjust the dose of insulin and oral drugs; pre-mixed group to stop taking oral medication, to protamine biosynthesis of human insulin [premixed 30R (Novo Spirit 30R)] treatment . Continuous treatment for 24 weeks and regular follow-up, observe the safety and efficacy of the two groups of treatment. Results After 24 weeks of treatment, the compliance of the basic group was significantly higher than that of the premixed group (87.0% vs 75.0%, P <0.05). The symptoms and the underlying hypoglycemia events were significantly lower than those of the basic group Pre-mixed group (9.2% vs 20.0%, P <0.05). The basal group’s Hb A1c compliance rate was higher than that of the pre-mixed group (81.6% vs 66.7%, P <0.05) (P> 0.05). Hb A1c in the basal group was significantly lower than that in the premixed group, but the difference was not statistically significant (P> 0.05). There was no serious adverse event in both groups. Conclusion Both basic and pre-mixed groups can effectively reduce Hb A1c, but the compliance of basic treatment group and Hb A1c compliance rate were significantly higher than those of premixed group. The incidence of hypoglycemic events was significantly lower than that of premixed group.