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网状内皮系统是机体防御机构的重要组成部分之一,它不但在免疫过程中,而且也在化学治疗过程中起着重要的作用。1933年 Krish-nan 发现当切脾猴感染疟疾后,感染程度显著严重,而奎宁疗效亦差。1934年 Kritchewski& Demidowa 等发现用台盼蓝阻断患疟鸟后,奎宁疗效差。1941年 Trager 在感染疟疾的鸡用墨汁阻断后,引起感染加重。而1949年 Rodhain 于切脾的棉鼠接种疟原虫后,亦
The reticuloendothelial system is one of the important components of the body’s defense mechanism. It not only plays an important role in the immune process but also in the course of chemotherapy. In 1933, Krish-nan discovered that when spleen monkeys were infected with malaria, the infection was significantly worse, and the curative effect of quinine was also poor. In 1934, Kritchewski & Demidowa found that quinine was not effective after blocking malaria with trypan blue. In 1941 Trager caused the infection to increase after the chicken infected with malaria was blocked with ink. In 1949, Rodhain’s spleened cotton rats were vaccinated with Plasmodium.