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眼镜蛇是我国主要常见毒蛇,眼镜蛇毒中含有心脏毒为主的混合毒,眼镜蛇毒(即神经毒及心脏毒)及其提纯的神经毒早已在国内临床上用于镇痛、治疗风湿关节炎及小儿麻痹症。而眼镜蛇毒及其心脏毒对内分泌的影响,特别是小剂量时对垂体——甲状腺轴的作用国内外研究甚少。Larsenp R等最早报告较大剂量眼镜蛇毒、心脏毒(眼镜蛇A及B)抑制甲状腺切片中碘的积蓄,推测此可能是增加细胞膜对碘离子的通透性的结果。本文主要用安全量(大鼠最大耐受量)的眼镜蛇毒研究其
Cobra is a common poisonous snake in China. The cobra venom contains a mixture of cardiotoxic drugs. Cobra venom (ie, neurotoxicity and cardiotoxicity) and its purified neurotoxicity have long been used for clinical analgesia and rheumatoid arthritis in China. Polio. The effects of cobra venom and its cardiotoxicity on endocrine, especially at low doses, have little research on the pituitary-thyroid axis at home and abroad. Larsenp R et al. first reported that larger doses of cobra venom and cardiotoxicity (Cobra A and B) inhibited iodine accumulation in thyroid sections, presumably by increasing the permeability of the cell membrane to iodide ions. This article mainly studied the cobra venom of safe amount (rat maximum tolerance)