【摘 要】
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Dear Editor,rn Coronary artery disease is a leading cause of mortality and morbidity worldwide.Blockade of effective blood flow to heart muscles results in card
【机 构】
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School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China;University of Ch
论文部分内容阅读
Dear Editor,rn Coronary artery disease is a leading cause of mortality and morbidity worldwide.Blockade of effective blood flow to heart muscles results in cardiac ischemia and myocardial infarction(MI).1 Many angiogenic factors are known to be elicited during Ml,indicating a natural response of the heart to induce the formation of new coronary vessels in an attempt to revascularize the ischemic myocardium.2,3 However,coronary vascular endothelial cells(VECs)do not have sufficient angiogenic potential to effectively repopulate all ischemic regions,and clinical trials aiming at inducing revascularization through the delivery of pro-angiogenic molecules after ischemia have invariably failed.4 During development,a significant portion of coronary VECs in ventricular free walls and septum are reported to arise from endocardium during fetal and neonatal stages.5-7 Nonetheless,adult endocardium barely contribute to coronary VECs in home-ostasis or after injuries such as Ml.8 Finding new ways to promote neovascularization of adult endocardium offers important clinical insights into developing potential new therapeutic approach for treating ischemic heart diseases.
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