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已证明外源性的17-胃泌素或类似的合成五肽胃泌素可加速鼠直结肠癌的生长,并显著缩短用药鼠的存活期。另外,胃窦分离术导致血高胃泌素状态时也显示致癌物质所诱发的结肠癌的生长速度增加。本研究旨在确定药理学因素引起的内源性高胃泌素血症是否会影响一种患具胃泌素受体的直结肠癌实验鼠的肿瘤生长和存活期。材料和方法全部采用6～8周龄体重18～25g同一基因型、纯合子种系的雄性BALB/C
It has been demonstrated that exogenous 17-gastrin or a similar synthetic pentagastrin can accelerate the growth of murine colon cancer and significantly reduce the survival of the treated mice. In addition, gastric antral dissociation leads to an increase in the rate of growth of colon cancer induced by a carcinogen when the blood is in the state of high gastrin. The aim of this study was to determine if endogenous hypergastrinmia caused by pharmacological factors would affect the tumor growth and survival of a mouse model of colorectal cancer with gastrin receptor. Materials and methods all used 6 to 8 weeks old body weight 18 ~ 25g the same genotype, homozygous male BALB / C