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作者对第一个具有N-亚胺甲基的氨基糖苷Dactimicin的肾毒性与阿司米星(Astromicin),以及一部分作为参照的氨基糖苷类丁胺卡那霉素、核糖霉素、卡那霉素和庆大霉素进行比较。当已失水的鼠肌注本品200mg/kg后,Dactimicin用血液尿素氮和血清肌酸酐没有引起改变,而参照氨基糖苷类对这两个参数却都引起了显著地升高。在给予40和80mg/kg·d,疗程11天或21天的鼠尿分析中,除检出核细胞和N-乙酰葡萄糖胺外,其余的尿液参数仅稍有改变。在分别给予Dactimicin和阿司米星20、40、80、120、180和270mg/kg,疗程11天或30天的更详尽的对比研究中,Dactimicin在大剂量时,对有核细胞和N-乙酰葡萄糖胺引起的改变很
The authors compared nephrotoxicity of the first aminoglycoside Dactimicin with N-imine methyl groups with Astromicin, as well as some of the aminoglycoside amikacin, ribostamycin, kanamycin Su and gentamicin for comparison. When dehydrated rat intramuscular injection of this product 200mg / kg, Dactimicin with blood urea nitrogen and serum creatinine did not cause change, while the reference aminoglycoside on both parameters have caused a significant increase. In rats with urinalysis at 40 and 80 mg / kg · d for either 11 days or 21 days of treatment, the remaining urine parameters were only slightly changed except for the detection of nuclear cells and N-acetylglucosamine. In a more detailed comparative study of Dactimicin and Asmicosin at 20, 40, 80, 120, 180 and 270 mg / kg, respectively, for either eleven or thirty days of treatment, Dactimicin administered to nucleated cells and N- Acetylglucosamine caused the change is very