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大骨节病是发生在山区农村的骨关节病,病区的生态特点是低温、低硒和食物品种单调。我们曾对东北、内蒙及陕西进行调查,结果表明:病区儿童的血及发硒水平低,血谷胱甘肽过氧化物酶活性低,病儿红细胞膜中的磷脂(PL)尤其磷脂酰胆碱(PC)含量低,可见胆固醇(Ch)/PL和鞘磷脂(SM)/PC的分子比降低。通过用病区粮喂养大鼠5个月发现动物出现一系列类似大骨节病的改变。讨论了大骨节病的发病基础。
Kashin-Beck disease is a bone-joint disease that occurs in rural areas of mountainous areas. The ecological characteristics of the ward are low temperature, low selenium and monotonous food varieties. We have conducted surveys in Northeast China, Inner Mongolia and Shaanxi Province. The results showed that children in the ward had lower levels of blood and selenium and lower glutathione peroxidase activity, phospholipids (PL) in the erythrocyte membranes of sick children, especially phosphatidyl Choline (PC) content is low, the molecular ratio of Cholesterol (Ch) / PL and sphingomyelin (SM) / PC is reduced. Five months after feeding rats with ward food, a series of similar changes in KBD were found. Discussed the incidence of Kashin-Beck disease basis.