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目的探讨盐酸戊乙奎醚治疗急性有机磷农药中毒的临床疗效和不良反应。方法78例急性有机磷农药中毒患者随机分为盐酸戊乙奎醚(长托宁)治疗组和阿托品对照组。两组患者均给予常规反复彻底洗胃,输液、利尿、导泻及对症支持等综合治疗,治疗组在此基础上采用长托宁和氯磷定解毒治疗,对照在常规处理的基础上采用阿托品与氯磷定解毒治疗。比较两组用药次数、中毒症状消失时间、CHE恢复时间、住院时间,以及不良反应的发生情况。结果长托宁治疗组用药次数、CHE恢复时间、症状消失时间及住院天数均少于阿托品对照组,差异有显著性(P<0.05)。长托宁治疗组不良反应的发生率总体上低于阿托品对照组,其中反跳、中间综合征及治疗药物中毒的发生率明显低于阿托品对照组,差异有统计学意义(P<0.01)。结论盐酸戊乙奎醚(长托宁)救治有机磷农药中毒疗效好,毒副作用小。
Objective To investigate the clinical efficacy and adverse reactions of penehyclidine hydrochloride in the treatment of acute organophosphorus pesticide poisoning. Methods A total of 78 patients with acute organophosphorus pesticide poisoning were randomly divided into penehyclidine hydrochloride group and atropine control group. Both groups were given routine repeated gastric lavage, infusion, diuretic, cathartic and symptomatic support and other comprehensive treatment, the treatment group on the basis of the use of penehyclidine and chlorpromazine detoxification treatment, the control in the conventional treatment based on the use of atropine And chlorine phosphorus detoxification treatment. The frequency of medication, the time of symptom? My disappearance, the recovery time of CHE, the length of hospital stay, and the incidence of adverse reactions were compared between the two groups. Results The treatment time of CHT treatment group was less than that of atropine control group (P <0.05), the recovery time of CHE, disappearance of symptoms and days of hospitalization. The incidence of adverse reactions in the penehyclidine group was generally lower than that in the atropine control group, and the incidence of rebound, intermediate syndrome and treatment drug poisoning was significantly lower than that of the atropine control group (P <0.01). Conclusion Penehyclidine hydrochloride (penehyclidine hydrochloride) is effective in treating organophosphorus pesticide poisoning with little toxic or side effects.