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目的分析沙利度胺治疗强直性脊柱炎(AS)的临床疗效。方法 60例强直性脊柱炎患者随机分为对照组和治疗组,每组30例。对照组采用柳氮磺胺吡啶(SASP)治疗,治疗组采用沙利度胺治疗,观察两组患者的C反应蛋白、红细胞沉降率、外周关节肿胀数、扩胸度、枕臂试验、Bath强直性脊柱炎疾病活动指数(BASDAI)、临床缓解时间情况,同时比较两组治疗总有效率。结果治疗组患者的各项指标情况在治疗后均优于对照组(P<0.05);且治疗组总有效率为93.3%,明显高于对照组的80.0%(P<0.05)。结论沙利度胺治疗强直性脊柱炎能够有效缓解症状,治疗效果显著,值得临床推广。
Objective To analyze the clinical efficacy of thalidomide in treatment of ankylosing spondylitis (AS). Methods Sixty patients with ankylosing spondylitis were randomly divided into control group and treatment group, 30 cases in each group. The control group was treated with sulfasalazine (SASP). The treatment group was treated with thalidomide. The C-reactive protein, erythrocyte sedimentation rate, peripheral joint swelling, chest enlargement, occipital arm test, Bath ankylotropism Spondylitis disease activity index (BASDAI), clinical remission time, while comparing the two groups the total effective rate. Results The indexes in the treatment group were better than those in the control group after treatment (P <0.05). The total effective rate in the treatment group was 93.3%, which was significantly higher than that in the control group (80.0%, P <0.05). Conclusion Thalidomide treatment of ankylosing spondylitis can effectively relieve symptoms, the treatment effect is significant, worthy of clinical promotion.