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白细胞介素（interleukin，IL）-1家族、IL-6、肿瘤坏死因子（tumor necrosis factor，TNF）-α、粒细胞-巨噬细胞集落刺激因子（granulocyte macrophage-colony stimulating factor，GM-CSF）等炎症因子所介导的生理性炎症反应参与卵泡发育、成熟及排卵过程，炎症因子异常表达引发病理性炎症反应，可导致排卵障碍及不孕，主要见于多囊卵巢综合征（polycystic ovary syndrome，PCOS）、子宫内膜异位症（endometriosis，EMS）、早发性卵巢功能不全（premature ovarian insufficiency，POI）、肥胖、甲状腺功能减退等疾病。本文围绕炎症因子对卵泡发育的生理作用以及在不同疾病中影响卵子发育的可能机制进行阐述，以期为排卵障碍性不孕的诊疗提供帮助。“,”The physiological inflammatory response mediated by inflammatory cytokines such as interleukin (IL)-1 family, IL-6, tumor necrosis factor (TNF)-α, granulocyte macrophage colony stimulating factor (GM-CSF) is involved in follicular development, maturation and ovulation. The abnormal expression of inflammatory cytokines causes pathological inflammatory response, which can lead to ovulation disorders and infertility, was mainly observed in polycystic ovary syndrome (PCOS), endometriosis (EMS), premature ovarian insufficiency (POI), obesity, hypothyroidism and other diseases. This paper focuses on the physiological effect of inflammatory cytokines on follicular development and the possible mechanism of affecting the development of oocytes in different diseases, in order to provide help for the diagnosis and treatment of ovulatory dysfunctional infertility.