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目的探讨sFas/sFasL、TNFα在过敏性紫癜患者发病中的作用。方法采用固相酶联免疫分析法检测75例HSP患者血清sFas/sFasL、TNFα水平。结果HSP患者血清sFas/sFasL、TNFα水平均高于健康对照组,HSP急性期患者血清sFas、TNFα显著高于缓解期,而sFasL水平未见显著差异。在75例HSP患者中,有31例sFas、sFasL水平同时升高,HSP急性期患者血清sFas的增高与TNFα增高呈正相关(r=0.498,P<0.01),而其他组间无相关性(P>0.05)。结论sFas水平与HSP的炎症程度有关,高浓度sFas、sFasL可抑制Ts细胞对Th的负向调节,血清sFas/sFasL、TNFα的水平与HSP发病有一定关系,血清sFas/sFasL、TNFα水平的检测有望为HSP的免疫生物治疗提供新思路。
Objective To investigate the role of sFas / sFasL and TNFα in the pathogenesis of allergic purpura. Methods Serum levels of sFas / sFasL and TNFα were detected by enzyme-linked immunosorbent assay in 75 patients with HSP. Results The serum levels of sFas / sFasL and TNFα in HSP patients were significantly higher than those in healthy controls. The serum levels of sFas and TNFα in HSP patients were significantly higher than those in remission patients, but there was no significant difference in sFasL levels. In 75 HSP patients, 31 cases of sFas and sFasL levels increased at the same time. The increase of serum sFas in patients with acute HSP was positively correlated with the increase of TNFα (r = 0.498, P <0.01), but no correlation was found between the other groups > 0.05). Conclusions The level of sFas is related to the degree of inflammation in HSP. High concentrations of sFas and sFasL can inhibit the negative regulation of Th on Ts cells. The levels of sFas / sFasL and TNFα in serum are correlated with the pathogenesis of HSP, and the levels of sFas / sFasL and TNFα It is expected to provide new ideas for immunobiotherapy of HSP.