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目的研究慢性丙型肝炎(chronic hepatitis C,CHC)患者血清脂联素和胰岛素抵抗(insulin resistance,IR)水平变化,探讨CHC与代谢综合征(metabolic syndrome,MS)的关系。方法选择2011年10月—2012年3月确诊的CHC患者40例为观察组,以同期健康体检者40名为对照组,测定两组血糖、脂联素及IR水平并比较。计量资料采用t检验,P<0.05为差异有统计学意义。结果血糖、脂联素和IR水平观察组分别为(6.27±3.15)mmol/L、(3 754.8±1 078.74)pg/ml、2.31±1.84,对照组分别为(5.16±0.36)mmol/L、(5 313.74±2 105.08)pg/ml、1.57±1.08,两组比较差异均有统计学意义(均P<0.05)。结论 CHC与MS有着重要的相关性,可从代谢性疾病方面入手为CHC的临床诊疗、防治提供新的依据。
Objective To investigate the changes of serum adiponectin and insulin resistance (IR) in patients with chronic hepatitis C (CHC) and to explore the relationship between CHC and metabolic syndrome (MS). Methods Forty CHC patients diagnosed from October 2011 to March 2012 were selected as the observation group. Forty healthy subjects in the same period were selected as the control group. The levels of blood glucose, adiponectin and IR were measured and compared. Measurement data using t test, P <0.05 for the difference was statistically significant. Results The levels of blood glucose, adiponectin and IR in the observation group were (6.27 ± 3.15) mmol / L, (3 754.8 ± 1078.74) pg / ml and 2.31 ± 1.84, respectively, and those in the control group were 5.16 ± 0.36 mmol / L, (5 313.74 ± 2 105.08) pg / ml and 1.57 ± 1.08, respectively. There was significant difference between the two groups (all P <0.05). Conclusions CHC has an important correlation with MS, and may provide a new basis for the clinical diagnosis and treatment of CHC from the aspects of metabolic diseases.