论文部分内容阅读
The relationship between a polymorphism at position - 670 in the Fas gene (TNFRSF6) and preterm premature rupture of membranes (PPROM) in multifetal pregnancies was examined. Buccal swabs from 119 mother- infant sets were analyzed for an adenine (A) to guanine (G) substitution at position - 670 in the TNFRSF6 promoter. Pregnancy outcome data were subsequently obtained. Analysis was by Fisher exact test. Maternal allele G homozygosity (TNFRSF6* G) was observed in 42.4% of 33 PPROM pregnancies as opposed to 19.5% of 77 with no spontaneous preterm birth (P =. 01). Similarly, TNFRSF6* G homozygosity was present in 37.5% of 32 first- born neonates from PPROM pregnancies as opposed to 18.7% of 75 uncomplicated pregnancies (P =. 04). PPROM occurred in 8 of 14 (57.1% ) pregnancies in which mother and all neonates were TNFRSF6* G homozygotes as opposed to 25 of 105 (23.8% )- cases in which uniform TNFRSF6* G homozygosity was not observed (P =. 02). A genetic variant in the Fas gene is associated with an increased rate of PPROM in multifetal pregnancies.
The relationship between a polymorphism at position - 670 in the Fas gene (TNFRSF6) and preterm premature rupture of membranes (PPROM) in multifetal pregnancies was examined. Buccal swabs from 119 mother- infant sets were analyzed for an adenine (A) to guanine Analysis was by Fisher exact test. Maternal allele G homozygosity (TNFRSF6 * G) was observed in 42.4% of 33 PPROM pregnancies as opposed to 19.5% of Similarly, TNFRSF6 * G homozygosity was present in 37.5% of 32 firstborn neonates from 18 to 75% uncomplicated pregnancies (P = .04). PPROM occurred in 8 of 14 (57.1%) pregnancies in which mother and all neonates were TNFRSF6 * G homozygotes as opposed to 25 of 105 (23.8%) - cases in which uniform TNFRSF6 * G homozygosity was not observed (P = .02). A genetic variant in the Fas gene is associate d with an increased rate of PPROM in multifetal pregnancies.