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人红细胞(RBC)在体内的寿命为115-120天,这相当于正常成人每天约有2×10~(11)个RBC被更新。问题是什么因素决定RBC的寿命,最终从循环中清除的生理机制是什么?由于年青RBC(YRBC)与衰老RBC(SRBC)的唾液酸(NAN)含量不同,人们便开始注意唾液酸糖化物(SGC、即唾液酸糖蛋白和/或唾液酸糖脂)在SRBC扣押中起作用的可能性。SRBC的NAN含量比YRBC低10-15%。如果RBC的NAN含量降低,则称为aRBC易被扣押。目前的研究已经鉴定了与RBC扣押有关的RBC表面发生的特异性反应,这是一个革命性的进展。早年的理论认为:RBC内某些酶类的衰变,或RBC膜不能伸缩使之不能通过肝、脾的毛细血管而被扣押。衰老因子糖肽的发现具有重要意义。业已证明多种SCG的糖侧链起着“邮政编码”的关键作用,由它决定细胞
The lifespan of human red blood cells (RBCs) in the body is 115-120 days, which is equivalent to about 2×10 11 RBCs being updated every day in normal adults. The question is what factors determine the longevity of RBCs, and what is the physiological mechanism for eventual clearance from the circulation? Because of differences in the sialic acid (NAN) content of young RBCs (YRBCs) and aging RBCs (SRBCs), people begin to pay attention to sialic acid saccharides ( The possibility of SGC, ie sialyl glycoprotein and/or sialic acid glycolipid, play a role in SRBC seizure. The NAN content of SRBC is 10-15% lower than that of YRBC. If the NAN content of RBCs is reduced, it is called aRBC and it is easily seized. Current research has identified specific reactions that occur on the surface of RBCs associated with RBC seizures, which is a revolutionary development. The theory in the early years believed that the decay of certain enzymes in RBCs, or the inability of RBC membranes to stretch, prevented them from being seized through the capillaries of the liver and spleen. The discovery of senescence factor glycopeptides is of great significance. It has been proved that the sugar side chains of various SCGs play a key role in the “zip code”, which determines the cells