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用特异性放免法测定33例高血压患者血浆甘丙素(GAL)水平,结果显示高血压患者的血浆GAL水平(19.57±1.74pg/ml),明显高于对照组(9.36±0.94pg/ml,P<0.001),GAL与MAP呈正相关(P<0.05),GAL与内皮素(ET)呈正相关(P<0.01).自发性高血压大鼠(SHR)血浆GAL水平亦明显高于正常大鼠(P<0.01),GAL与MAP亦呈正相关(P<0.05),提示GAL是高血压的重要发病因素之一,体内多种多肽活性物质的增加,可能促进了高血压的发生与发展.
The level of plasma GAL in 33 patients with hypertension was measured by specific radioimmunoassay. The results showed that the level of plasma GAL in hypertensive patients (19.57 ± 1.74pg / ml) was significantly higher than that of the control group (9.36 ± 0.94pg / ml, P (P <0.05), but there was a positive correlation between GAL and ET (P <0.01) .The plasma GAL level in spontaneously hypertensive rats (SHR) was also significantly higher than that in normal rats P <0.01). There was a positive correlation between GAL and MAP (P <0.05), suggesting that GAL is one of the important pathogenetic factors of hypertension. The increase of multiple polypeptide active substances in vivo may promote the occurrence and development of hypertension.