目的研究慢性胃炎患者血清ｓＩＬ＿２Ｒ及ＲＢＣ免疫功能的变化。方法内镜及病理检查确诊的慢性胃炎５１例和４０例正常对照组作血清ｓＩＬ＿２Ｒ（双抗体夹心ＥＬＩＳＡ法）及ＲＢＣＣ３ｂ受体花环率、ＲＢＣ免疫复合物花环率（酵母菌花环试验）测定。结果慢性胃炎患者血清ｓＩＬ＿２Ｒ水平（２７５０±２３１１ＫＵ／Ｌ）与正常对照组（１９０６±７９３ＫＵ／Ｌ）相比增高，ＲＢＣ免疫功能降低；上述改变在慢性萎缩性胃炎及合并Ｈｐ感染者更明显（Ｐ＜００１）。血清ｓＩＬ＿２Ｒ与ＲＢＣＣ３ｂＲＲ呈负相关（ｒ＝－０５７，Ｐ＜００１）；与ＲＢＣＩＣＲ呈正相关（ｒ＝０７２，Ｐ＜００１）。结论慢性胃炎患者有免疫功能紊乱，血清ｓＩＬ＿２Ｒ及ＲＢＣ免疫功能低下，可能与慢性胃炎的发生发展有关 Objective To study the changes of serum sIL_2R and RBC immune function in patients with chronic gastritis. Methods Serum sIL_2R (double antibody sandwich ELISA) and RBCC3b receptor rosette rate and RBC immune complex rosette rate (yeast rosette test) were determined in 51 patients with chronic gastritis and 40 normal controls diagnosed by endoscopy and pathology. Results The level of serum sIL_2R in patients with chronic gastritis (2750 ± 2311KU / L) was higher than that in the normal control group (1906 ± 793KU / L) and the immune function of RBC was decreased. The above changes were associated with chronic atrophic gastritis and Hp infection was more obvious (P <0  01). Serum sIL_2R was negatively correlated with RBCC3bRR (r = -0.57, P <0.01), and positively correlated with RBCICR (r = 0.72, P <0.01). Conclusion Patients with chronic gastritis have immune dysfunction, serum sIL_2R and immune function of RBC are low, which may be related to the occurrence and development of chronic gastritis