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儿童急性喘鸣发作约有40%与呼吸道病毒感染有关。近来研究表明呼吸道中病毒特异IgE抗体与疾病的严重程度有关。病毒IgE抗体复合物可以导致粘膜肥大细胞释放炎性介质如白细胞介素。在刺激试验期间,敏感的成年受试者的鼻咽分泌物中白细胞介素C_4(LTC_4)和其它花生四烯酸的代谢产物浓度均增加,但自然呼吸道病毒感染期间呼吸道中白细胞介素的浓度尚无资料。本文对1～4岁,平均年龄18个月的38名男孩和26名女孩进行研究。52名因上感进入急诊室,其中33名有喘鸣症状,其余19名不伴喘鸣。12名无呼吸道疾病的儿童作为对照组。实验标本为鼻咽分泌物,经鼻孔插入吸管,轻轻抽吸,做白细胞介素浓度检测同时
About 40% of children suffer from acute wheezing associated with respiratory virus infection. Recent studies have shown that respiratory virus specific IgE antibodies and the severity of the disease. Viral IgE antibody complexes can cause mucosal mast cells to release inflammatory mediators such as interleukins. Nasopharyngeal secretions of sensitive adult subjects increased the concentrations of interleukin C_4 (LTC_4) and other arachidonic acid metabolites during the stimulation test, but the concentration of interleukin in the respiratory tract during natural respiratory virus infection No information yet In this study, 38 boys and 26 girls, aged 1 to 4 years and an average of 18 months, were studied. Thirty-two patients had wheezing symptoms and the remaining 19 were not accompanied by wheezing due to the sensation of entering the emergency room. Twelve children without respiratory diseases served as control group. Experimental specimens of nasopharyngeal secretions, inserted into the nose through the straw, gently sucked, do interleukin concentration test at the same time