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目的:研究降钙素原对指导ICU危重患者抗菌治疗的临床价值和意义。方法:将88例ICU危重感染患者以数字法随机分成A组、B组两组,A组按照正常的治疗方法给予抗生素治疗,B组根据患者血清中的降钙素含量决定是否采用抗生素治疗。结果:两组患者治疗后在各项实验室指标比较和死亡人数的对比上差异均无统计学意义(P>0.05)。在抗生素的使用时间上,A组平均使用抗生素(14.21±2.35)d,多于B组(9.31±2.78)d,差异有统计学意义(P<0.05)。结论:降钙素原对感知机体的感染程度有临床效果,因此对降钙素原浓度的精确监测在临床上对减少抗生素的使用量有重大意义。
Objective: To investigate the clinical value and significance of procalcitonin in guiding antimicrobial therapy in critically ill patients with ICU. Methods: Eighty-eight ICU critically ill patients were randomly divided into group A and group B according to the digital method. Group A was treated with antibiotics according to normal treatment methods. Group B was treated with antibiotics according to the level of calcitonin in serum. Results: There was no significant difference between the two groups in the comparison of laboratory indexes and the number of death after treatment (P> 0.05). The antibiotic use time in group A was 14.21 ± 2.35 days on average, more than that in group B (9.31 ± 2.78) d, the difference was statistically significant (P <0.05). CONCLUSIONS: Procalcitonin has a clinical effect on the perception of the degree of infection in the body. Therefore, accurate monitoring of procalcitonin concentration is clinically significant for reducing the amount of antibiotics used.