给Wistar大鼠饮用含NaF(100m g/L)的蒸馏水90天,同时灌胃给予Na2SeO3 [0.1m g/(kgBW·d)]和/或ZnSO4[14.8 m g/(kgBW·d)]。生化、病理和超微病理检测结果表明氟可导致肾脏严重受损。其主要毒作用部位为肾近曲小管,脂质过氧化作用是氟肾毒性的机理之一。一定剂量的硒、锌可通过拮抗氟诱导的脂质过氧化作用拮抗氟致肾脏损伤,硒、锌合用的拮抗作用强于单纯给予硒或锌 Wistar rats were drank distilled water containing NaF (100 m g / L) for 90 days while intragastrically administered Na2SeO3 [0.1 m g / (kg BW · d)] and / or ZnSO4 [14.8 m g / (kg BW · d)]. Biochemical, pathological and ultrastructural pathological findings indicate that fluoride can cause severe kidney damage. The main toxic site of renal proximal tubule, lipid peroxidation is one of the mechanisms of toxic effects of nephrotoxicity. A certain dose of selenium and zinc can antagonize fluorine-induced renal damage by antagonizing fluoride-induced lipid peroxidation. The antagonism of selenium and zinc combination is stronger than that of selenium or zinc alone