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[目的]探讨食管/贲门双源癌的临床病理特征。[方法]采用问卷调查、家访、医院病案资料整理分析及病理学检查等方法,对豫北地区及河北磁县的双源癌患者资料进行收集整理。首次诊断的双源癌患者431例,另检出漏诊双源癌112例,共543例。[结果]双源癌男∶女=5.12∶1,高发年龄60～70岁。双源癌中食管癌和贲门癌均以Ⅱ期居多(55.56%、36.17%);食管癌以中分化为主(62.81%),而贲门癌以低分化为主(48.41%);食管癌发病部位以中段居多(66.67%);食管癌以髓质型和早期癌比例最高(均为33.07%),贲门癌以蕈伞型(29.92%)居多。双源癌家族史阳性率40.13%,男性高于女性(43.18%vs20.00%,P=0.049)。5年生存率17.54%。[结论]食管/贲门双源癌漏诊率高,发病以男性为主。5年生存率较低。
[Objective] To investigate the clinicopathological features of esophagus / cardia double-cell carcinoma. [Methods] The data of double-source cancer patients in Yubei Prefecture and Cixian County of Hebei Province were collected and analyzed by means of questionnaires, home visits, hospital medical record data analysis and pathological examination. The first diagnosis of double-cell carcinoma patients 431 cases, the other detected 112 cases of missed double-cell carcinoma, a total of 543 cases. [Results] Dual-source cancer male: female = 5.12:1, high incidence of 60 to 70 years old. Esophageal cancer and cardia cancer were predominant in stage Ⅱ (55.56%, 36.17%) in double-origin cancer, moderately differentiated in esophageal cancer (62.81%) and poorly differentiated cardia (48.41%), esophageal cancer The majority of the sites were in the middle (66.67%); the highest proportion of esophageal carcinoma was in medullary and early cancers (both was 33.07%); the majority of cardia cancer was myficoid type (29.92%). The positive rate of family history of double-cell carcinoma was 40.13%, higher in males than in females (43.18% vs20.00%, P = 0.049). 5-year survival rate of 17.54%. [Conclusion] The rate of misdiagnosis of esophagus / cardia double-cell carcinoma is high, with male predominance. 5-year survival rate is lower.