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目的进一步阐明孤啡吠在痛觉调制中的作用。方法；本实验在大鼠电刺激甩尾测痛模型上．观察了侧脑室（icu）及路内（it）注射孤啡肽对芬太尼镇痛效应的影响。结果：icu及it注射孤啡吠后可减弱芬太尼镇痛效应。结论：孤啡肽的致痛敏作用可能与其对抗由μ受体介导的痛抑制效应有关。
Objective To further elucidate the role of orphan bark in pain modulation. Methods; This experiment in the rat electric stimulation tailgating pain model. The effects of icu and injections of orphanin on the analgesic effect of fentanyl were observed. Results: ICU and it decreased the analgesic effect of fentanyl after injection of orphaninol. CONCLUSION: The pain-inducing effect of orphanin may be related to the antagonistic effect of μ-receptor-mediated pain suppression.