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为研究妊娠期皮下注射尼古丁对仔鼠发育和行为的影响。将24只孕鼠随机分为对照组、1.0 mg/kg、2.0 mg/kg和4.0 mg/kg组,每组6只。受孕第7天起至仔鼠出生皮下注射0、1.0、2.0、4.0 mg/kg尼古丁生理盐水溶液1 mL,1次/d。结果显示:早期神经反射,对照组仔鼠出生后第4天和第7天达标率高于各实验组;水迷宫实验,对照组仔鼠潜伏期(39.66±8.54)s,2.0 mg/kg组(55.96±8.51)s,4.0 mg/kg组(58.99±7.66)s;目标区域停留时间对照组仔鼠(41.22±6.23)s,1.0 mg/kg组(33.25±6.98)s,2.0 mg/kg组(30.33±8.21)s,4.0 mg/kg组(22.54±8.54)s;穿越平台
To study the effects of subcutaneous nicotine in pregnancy on the development and behavior of offspring. 24 pregnant rats were randomly divided into control group, 1.0 mg / kg, 2.0 mg / kg and 4.0 mg / kg group, 6 in each group. From the 7th day after conception, the pups were injected subcutaneously with 1 mL nicotine saline (0, 1.0, 2.0, 4.0 mg / kg) once a day. The results showed that the early neurological reflexes in control group were higher than those in experimental group on the 4th and 7th day after birth. The water maze test, the latent period of the offspring of control group (39.66 ± 8.54) s, 2.0 mg / kg group 55.96 ± 8.51) s and 4.0 mg / kg (58.99 ± 7.66) s respectively. The retention time in the target area was significantly lower in the control group (41.22 ± 6.23) s, 1.0 mg / kg group (30.33 ± 8.21) s and 4.0 mg / kg (22.54 ± 8.54) s, respectively