1950年,Germuth 和 Ottigel 首先征明可的松具有免疫抑制作用。1951年 Billingham、Krohn 等指出大剂量可的松可延长皮肤移植的存活。实验证明其延长的时间虽短,但有意义。20多年来,作为免疫抑制剂应用于自身免疫性疾病、过敏性疾病和同种异体移植方面都显示着重要作用。尽管其许多作用尚不十分清楚,不良反应较多,但仍不失为免疫抑制的首选药物。现就皮质类固醇在免疫抑制方面的药理作用简述如下。 In 1950, Germuth and Ottigel firstly demonstrated that cortisone has immunosuppressive effects. In 1951 Billingham, Krohn, etc. pointed out that high-dose cortisone can prolong the survival of skin grafts. Experiments show that the extension of time is short, but meaningful. For more than 20 years, it has been shown to play an important role as an immunosuppressive agent in autoimmune diseases, allergic diseases and allografts. Although many of its effects are not yet clear, and more adverse reactions, but still the first choice for immunosuppressive drugs. The pharmacological effects of corticosteroids in immunosuppression are summarized below.