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目的观察产妇及其娩出的新生儿乙肝标志物即表面抗原(HBsAg)、表面抗体(抗HBs或HBsAb)、e抗原(HBeAg)、e抗体(抗HBe或HBe Ab)、核心抗原(HBc Ag)、核心抗体(抗HBc或HBcAb)和外膜蛋白前S1抗原(Pre-S1抗原)之间的相关性。方法选择2012年1月-2013年12月在该院分娩的孕妇及新生儿200对,对其血清分别进行酶联免疫吸附实验(ELISA)行检测,按照HBsAg结果分为阴性组和阳性组,用SPSS软件分析分析产妇与其新生儿各项标志物S/CO值间的相关性。结果 HBsAg阳性的母亲,其产出的新生儿HBsAg阳性率为6.25%(6/96)。母亲HBsAg、Pre-S1抗原的S/CO值与新生儿的HBsAb、HBe Ab、HBcAb的S/CO值均呈负相关,与新生儿的HBeAg呈正相关;母亲HBsAb的S/CO值均与新生儿的HBsAb、HBcAb的S/CO值均呈正相关;母亲HBe Ab、HBcAb的S/CO值均与新生儿的HBsAb、HBe Ab、HBcAb的S/CO值均呈正相关。结论母亲的乙肝病毒状态与其娩出的新生儿的乙肝六项检测结果有密切关系。
Objective To observe the relationship between hepatitis B virus (HBsAg), surface antibody (anti-HBs or HBsAb), e antigen (HBeAg), e antibody (anti-HBe or HBe Ab), core antigen , The correlation between the core antibody (anti-HBc or HBcAb) and the outer membrane pre-S1 antigen (Pre-S1 antigen). Methods 200 pairs of pregnant women and newborn infants delivered from January 2012 to December 2013 in our hospital were selected and their serums were tested by enzyme linked immunosorbent assay (ELISA). According to the results of HBsAg, they were divided into negative group and positive group, SPSS software analysis of maternal and neonatal markers S / CO correlation between the value. Results HBsAg positive mothers, the output of neonatal HBsAg positive rate was 6.25% (6/96). The S / CO values of maternal HBsAg and Pre-S1 antigens were negatively correlated with the S / CO values of neonates with HBsAb, HBe Ab and HBcAb, and positively correlated with the HBeAg of the newborn The S / CO values of HBsAb and HBcAb in children were positively correlated. The S / CO values of HBe Ab and HBcAb in mothers were positively correlated with the S / CO values of HBsAb, HBe Ab and HBcAb in neonates. Conclusion The status of the mother’s hepatitis B is closely related to the results of the six tests of hepatitis B in her newborn infants.