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本工作研究了36.5米和50米氮氧饱和暴露对人体二氧化碳通气反应的影响。用重复呼吸法测定了两组共13名健康男性受试者的二氧化碳通气反应。氮氧饱和条件下的氧分压维持在0.30绝对压左右,而测定通气反应时的吸入气中的氧分压是0.98绝对压,二氧化碳分压是0.07绝对压,其余为氮气。此外,还测定了受试者的终末潮气二氧化碳分压。实验结果表明:1.二氧化碳通气反应随压力升高而下降。2.二氧化碳通气反应曲线的截距在不同深度均未见有明显的变化。3.在高压条件下,静息状态的终末潮气二氧化碳分压比常压对照值有明显的增加。高压下的二氧化碳通气反应的下降和终末潮气二氧化碳分压的升高,在减压返回海平面后均能恢复到常压水平。高压下的这些变化,可能是呼吸中枢对二氧化碳敏感性的改变所致,也可能是由于呼吸阻力增加引起的呼吸功增加所致,或是两个因素叠加的结果。
This work studied the effects of nitrogen and oxygen saturation exposure of 36.5 meters and 50 meters on the body’s carbon dioxide ventilation. Carbon dioxide ventilation was measured in 13 healthy male subjects in the two groups by repeated respiration. The oxygen partial pressure under the nitrogen-oxygen saturation condition is maintained at about 0.30 absolute pressure, and the oxygen partial pressure in the intake gas when the ventilation reaction is measured is 0.98 absolute pressure, the partial pressure of carbon dioxide is 0.07 absolute and the balance is nitrogen. In addition, the subject’s final moisture carbon dioxide partial pressure was also determined. The experimental results show that: 1. The carbon dioxide ventilation reaction decreases with increasing pressure. 2. The intercept of carbon dioxide aeration response curve has no obvious change at different depths. 3. At high pressure, resting end-point moisture partial pressure of carbon dioxide significantly increased compared with the normal pressure control value. The reduction of carbon dioxide ventilation reaction under high pressure and the increase of partial pressure of moisture at the end of moisture can be restored to atmospheric pressure after decompression return to sea level. These changes under high pressure may be due to changes in the carbon dioxide sensitivity of the respiratory center, may also be due to increased respiratory resistance caused by increased work of breathing, or a result of the superposition of two factors.