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内毒素被认为与创伤及脓毒血症时血循环改变有关.大剂量的内毒素可直接损伤血管内皮细胞,或通过补体替代途径及诱发血管内凝血间接损害血管,导致器管功能障碍和血管通透性改变.反复小剂量注入内毒素则可使机体对内毒素耐受,提高枯否氏细胞的吞噬功能.本实验研究反复小剂量内毒素对循环纤维结合素、调理素及网状内皮系统吞噬功能的作用.
Endotoxins are thought to be associated with changes in blood circulation during trauma and sepsis, and large doses of endotoxin can directly damage vascular endothelial cells, indirectly impairing blood vessels through complement replacement pathways and inducing intravascular coagulation, leading to dysfunction of the tube and vascular access Permeability changes. Repeated small doses of endotoxin can endotoxin tolerance of the body to improve the phagocytosis of Kupffer cells.In this study, repeated small doses of endotoxin on circulating fibronectin, opsonin and reticuloendothelial system Function of phagocytosis.