论文部分内容阅读
病毒专家认为第一次病毒感染通常被后继的病毒感染所干扰,1957年 Isaacs 和 Lindenmann 对此进行了令人鼓舞的连续观察,他们称由感染细胞释放的因子为干扰素。简短地说,热灭活的流感病毒与经绒毛筷尿囊培养过夜。若将培养液的上层清液加入新鲜组织培养物,则活病毒的生长受到抑制。早在1935年 Hoskins 就曾确切地描述了这一现象,但是实验未阐述清楚。已知干扰素的机制是一种特殊病毒可干扰继发感染:破坏受体;感染使与缺陷颗粒竞争;内在性竟争核糖核甙酸节段的配对;竞争必要的生长元素,以及生产抑制性激素——干扰素。
Viral experts believe that the first viral infection was usually interfered by subsequent viral infections. In 1957, Isaacs and Lindenmann made encouraging observations on this. They called the factor released by infected cells as interferon. Briefly, heat-inactivated influenza virus was incubated overnight with choriochondrium chorio-alteola. If the supernatant of the culture medium is added to the fresh tissue culture, the growth of live virus is inhibited. As early as 1935 Hoskins had described this phenomenon exactly, but the experiment was not clear. The known mechanism of interferon is that a particular virus can interfere with secondary infections: destroying the receptor; infections compete with defective particles; internality competes for pairing of ribonucleic acid segments; necessary growth elements for competition, and production inhibition Sex hormone - interferon.