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近年来的一些动物和人体研究显示,以脂肪因子为靶目标的治疗在肥胖及其相关代谢性疾病的干预中可获得减重、改善胰岛素抵抗及降糖的作用[1]。本文将对基于脂肪因子的肥胖相关代谢性疾病治疗进展进行综述。1瘦素(Leptin)瘦素是由脂肪细胞分泌的蛋白类激素,主要由白色脂肪组织产生,其血浆浓度与机体的脂肪总量呈正相关。瘦素作用于下丘脑的代谢调节中枢,可以激活PI3K信号通路,增加机体对葡萄糖的摄取利用。同时,瘦
In recent years, a number of animal and human studies have shown that treatment with adipokines targets to gain weight, improve insulin resistance and reduce blood sugar in the intervention of obesity and its related metabolic diseases [1]. This article reviews the progress in the treatment of obesity-related metabolic diseases based on adipokines. Leptin (Leptin) Leptin is a protein hormone secreted by fat cells, mainly produced by white adipose tissue, the plasma concentration and body fat was positively correlated. Leptin acts on the metabolic regulation center of the hypothalamus, activating the PI3K signaling pathway and increasing the organism’s utilization of glucose. At the same time, thin