固体分散体是将药物用熔融法、共沉淀法或溶融—溶剂法分散在无生理活性或易溶于水的载体中成为高度分散状态的固体分散物(Solid Dispersions,SDS)的一种制剂技术。本技术在1961年由Sekiguchi等首先提出,并以尿素为载体,用熔融法制备了磺胺噻唑固体分散体。实验结果表明,口服这种固体分散体以后,其吸收及排泄均比口服单纯磺胺噻唑增加,改变了难溶性药物的水溶性和生物利用度;此后,人们对 A solid dispersion is a preparation technique of solid Dispersions (SDS) in which a drug is dispersed in a physiologically inactive or water-soluble carrier in a highly dispersed state by melt method, co-precipitation method or melt-solvent method . The technology was first proposed by Sekiguchi et al in 1961 and urea solid solution was prepared by melt method sulfathiazole solid dispersion. The experimental results show that oral administration of this solid dispersion, the absorption and excretion than oral sulfathiazole increased, changing the water solubility and bioavailability of insoluble drugs; Since then, people are right