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放射性脑病(Radiation Encephalopathy, RE)是鼻咽癌放疗后的严重并发症,发病率为1.03%。尽管放射技术的更新,但随着鼻咽癌患者生存期的延长,面颈联合野的常规使用,特别是CT和MRI等影像手段的普遍开展,RE的检出率有增加的趋势。目前,对于RE尚无特效的治疗方法,因此,深入研究其发生规律,探讨防治有效方法具有重要意义。本文就其研究现状作一综述。 1 发病机制 RE的发病机制尚不完全清楚,主要有三大假设:(1)放射线直接损伤脑神经组织。其依据是病变发生在放射野区最为严重,如两侧颞叶,脑干。李振权等对鼻咽癌放疗后
Radiation encephalopathy (RE) is a serious complication of nasopharyngeal carcinoma after radiotherapy, the incidence was 1.03%. Despite the renewal of radiological techniques, the detection rate of RE tends to increase with the prolonged survival of patients with nasopharyngeal carcinoma and the routine use of facial and cervical joint fields, especially with the widespread use of imaging modalities such as CT and MRI. At present, there is no effective treatment for RE, therefore, it is of great significance to study its occurrence rules in depth and explore effective prevention and treatment methods. This article reviews its research status. 1 pathogenesis RE pathogenesis is not yet fully understood, there are three major hypotheses: (1) radiation directly damage brain tissue. The basis is that lesions occur in the most serious area of radiation, such as the temporal lobe, brain stem on both sides. Li Zhen right after radiotherapy for nasopharyngeal carcinoma