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目前,较有成效的透皮吸收增强剂按其结构特点可以划分为以下几类: 1.亚砜类包括二甲基亚砜、油酸甲基亚砜、癸基甲基亚砜等。 2.取代甲酰胺类包括二甲基甲酰胺、二乙基甲酰胺、N,N-二乙基-m-甲苯甲酰胺、二甲基月桂酰胺等。 3.氮杂环酮类包括2-吡咯烷酮,1-甲基-2-吡咯烷酮、1-乙基-2-吡咯烷酮、十二烷基吡咯烷酮、1-苄基-氮杂环戊烷-2-酮、1-苯基-氮杂环戊烷-2-酮、1-十二烷基-氮杂环庚烷-2-酮等。 4.n-烷烃基离子表面活性剂如十二烷基硫酸钠。 5.其它如癸二酸二异丙基酯等。其中已证明二甲基亚砜具有膜渗透作用,能增强氢化可的松和睾丸素的透皮吸收,在水杨酸亲水性油膏中加入15％二甲基亚砜能提高水杨酸的透皮吸收;二甲基亚砜能促
At present, more effective percutaneous absorption enhancer according to its structural characteristics can be divided into the following categories: 1. Sulfoxides, including dimethyl sulfoxide, methyl olefine sulfoxide, decyl methyl sulfoxide and so on. 2. The substituted carboxamides include dimethylformamide, diethylformamide, N, N-diethyl-m-toluamide, dimethyllauramide and the like. 3. Azacyclic ketones include 2-pyrrolidone, 1-methyl-2-pyrrolidone, 1-ethyl-2-pyrrolidone, dodecylpyrrolidone, 1 -benzyl-azacyclopentan-2-one , 1-phenyl-azacyclopentan-2-one, 1-dodecyl-azepan-2-one and the like. 4. n-Alkyl-based ionic surfactants such as sodium lauryl sulfate. Others such as diisopropyl sebacate. It has been shown that dimethylsulfoxide has a membrane-permeation effect, which enhances the transdermal absorption of hydrocortisone and testosterone. The addition of 15% dimethylsulfoxide to the salicylic acid hydrophilic ointment increases salicylic acid Transdermal absorption; dimethyl sulfoxide can promote