健康成年未经产Sprague-Dawley 大鼠,受孕后第6—15天器官形成期阶段,经口摄入四甲基二硫(?)酰胺(TMTD)112mg/kg(1/5LD_(5?))共6次,出现明显胚胎毒和致畸胎作用.胎鼠吸收率及死缓率分别为38.2及4.3%,明显高于对照组5.2及0%,所产仔鼠胎重、身长、尾长及胎盘重量显著低于对照组。对多种骨骼发育如枕骨和颈椎骨骨化迟缓,胸、肋骨明显缺失及融合均有影响且有外 Healthy adults without Sprague-Dawley rats, 6 to 15 days after conception organ formation stage, oral intake of tetramethyldisulfide (TMTD) 112mg / kg (1 / 5LD_ (5?) ) Had obvious embryo toxicity and teratogenic effects, and the fetal rat fetus rate and death rate were 38.2% and 4.3% respectively, which were significantly higher than those of control group (5.2% and 0%) And placental weight was significantly lower than the control group. For a variety of skeletal development such as occipital and cervical ossification ossification, chest, significant loss of ribs and fusion are affected and outside