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目的 探讨细胞核仁形成区活性与反复自发流产的关系。方法应用银梁ＮＯＲ技术，对反复自发流产患者夫妇和有正常生育史夫妇各３０对的中期染色体核仁形成区银染点（Ａｇ－ＮＯＲ）和近端着丝粒染色体银染联合（Ａｇ－ＡＡ）数进行对比分析。结果反复自发流产夫妇 Ａｇ－ＮＯＲ数量和女性Ａｇ－ＡＡ次数分别为６．７２，６．３９和０．３７，明显高于对照组的６．０７，５．８６和０．３１，二者间有显著性差异（Ｐ＜０．０１，Ｐ＜０．０５）。结论细胞核仁形成区活性增高是引起反复自发流产的重要因素。
Objective To investigate the relationship between nucleolar amyloidogenic activity and recurrent spontaneous abortion. Methods Silver beam NOR technique was used to detect the Ag-NOR and Ag-NOR in 30 pairs of couples with spontaneous abortion and those with normal fertility history respectively. AA) for comparative analysis. Results The number of Ag-NOR couples and female Ag-AA patients with repeated spontaneous abortion were 6.72, 6.39 and 0.37, respectively, which were significantly higher than 6.07, 5.86 and 0.31 of the control group There was significant difference (P <0.01, P <0.05). Conclusions Increased activity of nucleolar organizer region is an important factor for repeated spontaneous abortion.