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本文报导了以血浆和眼房水中的2-肟甲基-N-甲基吡啶离子浓度作为甲磺酰派姆(2-肟甲基N-甲基吡啶甲烷磺酸盐)对兔子的毒性指标,对甲磺酰派姆的作用进行了研究。甲磺酰派姆是治疗有机磷农药中毒,使胆碱酯酶复能的药物。成年雌兔一次肌注甲磺酰派姆半数致死剂量(258mg/kg)或者静注甲磺酰派姆半数致死剂量(118mg/kg)之后,在2小时内的不同时间里测定了血浆中甲磺酰派姆的浓度。结果表明,雌兔死亡时的血浆甲磺酰派姆浓度一般都大于200μg/ml;若血浆浓度在90～160μg/ml,即使持续几分钟也不致死,但如再
This paper reports the concentration of 2-oxime methyl-N-methyl pyridine in plasma and aqueous humor as a toxicological indicator of rabbit toxicity of mesylate (2-oxime methyl N-methylpyridine methanesulfonate) , The role of methanesulfonamide has been studied. Methanesulfonyl Pyramide is the treatment of organophosphorus pesticide poisoning, cholinesterase re-energy drugs. After a single intramuscular injection of methaqualone at a median lethal dose (258 mg / kg) or a median lethal dose of methanesulfonylmethol (118 mg / kg) in adult female rabbits, the plasma level of a Sulfonyl group of the concentration. The results showed that female rabbits at the time of death plasma methanesulfonyl pyramide concentration are generally greater than 200μg / ml; if the plasma concentration of 90 ~ 160μg / ml, even for a few minutes do not die, but if then