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恶性肿瘤病人进行骨髓移植(BMT)治疗后恶性肿瘤的复发对癌症病人来说仍然是一个主要难题.过继免疫治疗极有可能是有效的预防方法之一.首先采用C57BL/6鼠建立荷结肠腺癌(MCA-38)模型,将MCA-38细胞株经尾静脉注入小鼠,该鼠将因为肿瘤定向转移于肺而导致死亡.荷瘤后10天对小鼠进行致死剂量照射,同时给予同基因骨髓移植(BMT)并加脾细胞移植悬液(SC)移入,在此基础上给予重组人催乳素(rhPHL)(10μg/天,连续10天,ip).实验分为单纯
The recurrence of malignant tumors after bone marrow transplantation (BMT) in patients with malignant tumors is still a major problem for cancer patients. Adoptive immunotherapy is very likely to be one of the effective methods of prevention. The first use of C57BL/6 mice to establish the colon colon gland In the MCA-38 model, the MCA-38 cell line was injected into mice via the tail vein. The mice will die due to tumor metastasis to the lungs. The mice will be lethally dosed for 10 days after tumor-bearing. Gene bone marrow transplantation (BMT) plus spleen cell transplantation suspension (SC) transfer, based on which to give recombinant human prolactin (rhPHL) (10μg/day, continuous 10 days, ip). The experiment was divided into simple