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目的探讨血管紧张素转换酶抑制剂(ACEI)的不良反应及其处理措施,以提高临床合理用药水平。方法对中国化学工程第十一建设有限公司医院2007年7月至2011年7月应用血管紧张素转换酶抑制剂引起的药物不良反应进行回顾性分析,并提出相应的处理措施。结果本研究出现不良反应34例,发生率为16.2%。其中咳嗽10例,首剂低血压8例,肾功能损害6例,高血钾4例,心律失常3例,血管性水肿2例,味觉改变1例。结论 ACEI类药物产生不良反应的原因是多方面的,临床医师应高度重视ACEI类药物的不良反应,尽量避免,积极防治,最大程度上减少其不良反应的发生,确保临床用药安全。
Objective To investigate the adverse reaction of angiotensin converting enzyme inhibitor (ACEI) and its treatment measures to improve the clinical rational use of drugs. Methods Retrospective analysis was made on adverse drug reactions caused by angiotensin converting enzyme inhibitors during the period from July 2007 to July 2011 in the 11th Hospital of China Chemical Engineering, and the corresponding treatment measures were put forward. Results There were 34 cases of adverse reactions in this study, the incidence was 16.2%. One cough in 10 cases, the first dose of hypotension in 8 cases, renal damage in 6 cases, 4 cases of hyperkalemia, arrhythmia in 3 cases, 2 cases of angioedema, taste changes in 1 case. Conclusions There are many reasons for the adverse reactions of ACEIs. Clinicians should attach great importance to the adverse reactions of ACEIs, avoid them as much as possible, and prevent them from being adverse reactions as much as possible to ensure the safety of clinical medication.