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目的:评价依普黄酮固体分散体在大鼠体内的药物动力学行为。方法:测定它的药物动力学参数和相对生物利用度,采用高压液相色谱法测定大鼠血浆中依普黄酮的浓度。结果:大鼠灌胃依普黄酮固体分散体250mg·kg~(-1),其血药浓度-时间曲线符合一室模型,药物动力学参数为:K_e=0.21h~(-1),T_(1/2K_e)=5.19h,K_a=1.71h~(-1),T_(1/2K_a)=0.41h,T_(max)=0.67h,C_(max)=429μg·L~(-1),AUC=3916μg·h·L~(-1),相对生物利用度是323％。结论:依普黄酮固体分散体与依普黄酮的物理混合物比较,在大鼠体内有更多被吸收。
OBJECTIVE: To evaluate the pharmacokinetics of ipriflavone solid dispersion in rats. Methods: Its pharmacokinetic parameters and relative bioavailability were determined. The concentration of ipleprolide in rat plasma was determined by high pressure liquid chromatography. Results: The concentration-time curve of plasma concentration-time curve of ipiprofloxacin was intragastrically administered in a one-compartment model. The pharmacokinetic parameters were as follows: K_e = 0.21 h -1, T_ (1 / 2K_e) = 5.19h, K_a = 1.71h -1, T_ (1 / 2K_a) = 0.41h, T_max = 0.67h, C_max = 429μg · L -1 , AUC = 3916μg · h · L -1, relative bioavailability was 323%. Conclusion: Ipraflavone solid dispersion is more absorbed in rats than physical mixtures of ipriflavone.