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目的:探讨清热固胎汤联合黄体酮治疗血热型复发性流产的临床效果。方法:选择血热型复发性流产患者为本次研究对象,按照随机自愿的原则分为治疗组和对照组。两组在常规临床治疗的基础上,均给予黄体酮,治疗组在此基础上加服自拟清热固胎汤,以7 d为1个疗程,连续治疗4个疗程。治疗后,观察比较两组患者治疗前后症状体征变化,并检测分析治疗前后患者血清性激素、相关免疫抗体和细胞因子的含量变化。结果:治疗组治疗后愈显率为62.8%,总有效率为90.7%;对照组分别为35.3%、72.1%,治疗组优于对照组(P<0.05);治疗后,两组血清E2、P以及β-HCG含量均显著升高(P<0.05),且治疗组治疗后血清E2、P以及β-HCG含量均显著高于对照组(P<0.05);治疗后,两组血清IL-2含量均显著降低(P<0.05),而IL-4含量均显著升高(P<0.05),治疗组治疗后血清IL-2含量显著低于对照组(P<0.05),而IL-4含量显著高于对照组(P<0.05);治疗后,治疗组As Ab、Ao Ab、Em Ab及Ac Ab抗体转阴率均显著高于对照组(P<0.05)。结论:清热固胎汤联合黄体酮治疗血热型复发性流产,能够调节患者内分泌功能,抑制和改善病理性免疫反应。
Objective: To investigate the clinical effect of Qingre Guxie Decoction combined with progesterone in the treatment of blood-heat-induced recurrent spontaneous abortion. Methods: The patients with blood-heat-induced recurrent spontaneous abortion were selected as the study subjects and divided into treatment group and control group randomly and voluntarily. On the basis of routine clinical treatment, both groups were given progesterone. On the basis of this, prolactin was added to the treatment group, taking 7 days as a course of treatment and 4 courses of continuous treatment. After treatment, the changes of symptoms and signs before and after treatment were observed and compared between the two groups. The levels of serum sex hormones, related immune antibodies and cytokines were measured before and after treatment. Results: The cure rate of the treatment group was 62.8% and the total effective rate was 90.7%. The control group was 35.3% and 72.1% respectively. The treatment group was better than the control group (P <0.05) P and β-HCG were significantly increased (P <0.05), and the levels of E2, P and β-HCG in the treatment group were significantly higher than those in the control group (P <0.05). After treatment, the levels of IL- (P <0.05), while the content of IL-4 was significantly increased (P <0.05), while the content of IL-2 in the treatment group was significantly lower than that in the control group (P <0.05) (P <0.05). After treatment, the antibody negative rates of As Ab, Ao Ab, Em Ab and Ac Ab in the treatment group were significantly higher than those in the control group (P <0.05). Conclusion: Decoction combined with progesterone in treating heat-recurrent abortion can regulate endocrine function and inhibit and improve the pathological immune response.