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Angew.Chem.Int.Ed.2014,53,1410~1414通过过渡金属催化的炔丙基取代反应,可以非常便利地在反应产物上引入富电子的碳碳叁键官能团,进而可以实现多种复杂化合物的合成.因此这一反应近来受到越来越多的关注并取得了很大的进展.多种过渡金属如Ru、Cu、Ni等及氮、氧、碳等亲核试剂已被成功应用于该反应中.但利用简单的酮及其烯醇衍生物作为亲核试剂的炔丙基取代化反应目前仍鲜有成功的报导.中国科学院大连化学物理研究所胡向平研究员和徐杰研究员等利用手性铜催
Angew.Chem.Int.Ed.2014,53,1410-1414 Through the transition metal-catalyzed propargyl substitution reaction, it is very convenient to introduce electron-rich carbon-carbon triple bond functional groups into the reaction product, so that various complicated Compounds have attracted more and more attention recently and great progress has been made.Many transition metals such as Ru, Cu, Ni and so on, as well as nitrogen, oxygen, carbon and other nucleophiles have been successfully applied to However, the reaction of propargyl substitution using simple ketones and their enol derivatives as nucleophiles is still rarely reported successfully. Researchers Hu Xiangping and Xu Jie from Dalian Institute of Chemical Physics, Chinese Academy of Sciences Chiral copper catalyst