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幽门螺杆菌(Hp)是一种微需氧的革兰阴性菌,电镜下它是一种单端多鞭毛、末端钝圆、菌体作螺旋形弯曲的细菌,它定植在人类上消化道,尤其是在胃中。现已证明Hp感染非常普遍,而且它是引起B型胃炎、消化道溃疡以及粘膜相关性淋巴组织(MALT)淋巴瘤等疾病的主要致病因子。目前主要依靠抗生素清除Hp,虽然Hp在体外对多种抗生素敏感,但是在体内抗生素治疗往往不能奏效,即使有效也不能阻止Hp的再次感染。许多研究人员尝试了通过口服疫苗来阻断Hp的感染,口服疫苗是诱导粘膜免疫力,从而防止Hp感染的一种安全、方便的方法。
Helicobacter pylori (Hp) is a microaerophilic gram-negative bacteria, which is a single-ended multi-flagella, a blunt end of the cell, spiral bacteria bacteria bacteria, which is colonized in the human upper gastrointestinal tract, Especially in the stomach. It has been demonstrated that H. pylori infection is prevalent and that it is the major causative agent of diseases causing type B gastritis, peptic ulcer and mucosa-associated lymphoid tissue (MALT) lymphoma. At present, antibiotics are mainly used to eliminate Hp. Although Hp is sensitive to many kinds of antibiotics in vitro, in vivo antibiotic treatment often can not work, and even if effective, it can not prevent the reinfection of Hp. Many researchers have tried to block the infection of Hp by oral vaccines, a safe and convenient method of inducing mucosal immunity and thus preventing Hp infection.