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【目的】探讨丹参静脉滴注对早期糖尿病肾病(Diabetic nephropathy,DN)患者外周血自噬相关蛋白表达的影响。【方法】61例早期DN患者遵照患者意愿分为对照组和观察组,两组均口服降糖药物格列美脲片每次2 mg,1次/日,观察组同时每天注射用丹参(冻干)粉针剂1200 mg加入木糖醇250 mL 静脉滴注,14 d为一疗程,连续二个疗程。检测两组患者治疗前后24 h 尿白蛋白排泄总量(UAER)、24 h 尿蛋白总量(Upro)、血清肌酐(SCr)、尿素氮(BUN)和肾小球滤过率(eGFR)及外周血自噬相关蛋白 p62和 LC3的表达水平并比较。【结果】对照组治疗后 UAER、Upro、BUN、SCr 和 eGFR 等指标与治疗前比较差异无统计学意义(P >0.05),但观察组治疗后的 UAER、24hUpro、BUN、SCr 和 eGFR 较治疗前显著降低(P 0.05),观察组治疗后LC3 mRNA 表达水平较治疗前显著升高(P <0.05),p62抗体阳性率较治疗前显著降低(P 0.05),but after treatment,the UAER, 24hUpro、BUN、SCr and eGFR of the observation group was significantly decreased compared with those be-fore treatment (P 0.05);the expression level of LC3 mRNA of the treatment group was significantly increased compared to that before treatment (P <0.05),the p62 an-tibody positive rate was significantly decreased compared with that before treatment (P <0.05).[Conclusion]Danshen powder intravenous infusion has protective effect on kidney in early stage of DN,and its mechanism may be related to the intervention of autophagy.
