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目的观察不同血糖水平血清脂肪细胞脂肪酸结合蛋白(A-FABP)水平,探讨其与IR的相关性。方法选取NGT组55名、IGT组53例及T2DM组56例,测定各组血清A-FABP、FPG、2 hPG、TC、TG、FIns等指标,计算BMI,WHR及胰岛素抵抗指数(HOMA-IR),分析A-FABP与IR的相关性。结果 T2DM组血清A-FABP水平高于IGT组和NGT组[(71.14±10.03)vs(36.69±8.01)vs(19.49±2.98)mg/L,P<0.05]。相关分析显示,血清A-FABP水平与BMI、WHR、TC、TG、HDL-C、LDL-C、HbA_1c、2 hPG、高敏C反应蛋白(hsC-RP)、HOMA-IR相关(r=0.739、0.320、0.202、0.213、0.695、0.248、0.842、0.441、0.354、0.695,P<0.05或P<0.01)。多元回归逐步分析显示,BMI、WHR、HbA_1c、HOMA-IR是影响血清A-FABP的独立危险因素(t=2.621、4.461、7.362、3.875,P<0.05)。结论 A-FABP与IR关系密切,随着IR程度的加重,A-FABP水平逐渐升高。
Objective To observe the level of A-FABP in serum of different blood glucose levels and to explore its correlation with IR. Methods Fifty-five NGT patients, 53 IGT patients and 56 T2DM patients were enrolled in this study. Serum A-FABP, FPG, 2 hPG, TC, TG, FIns and other indexes were measured and BMI, WHR and HOMA-IR ), Analysis of A-FABP and IR correlation. Results The level of serum A-FABP in T2DM group was significantly higher than that in IGT group and NGT group [(71.14 ± 10.03) vs (36.69 ± 8.01) vs (19.49 ± 2.98) mg / L, P <0.05]. Correlation analysis showed that serum A-FABP levels were correlated with BMI, WHR, TC, TG, HDL-C, LDL-C, HbA 1c, 2 hPG, hsC-RP and HOMA- 0.202, 0.213, 0.695, 0.248, 0.842, 0.441, 0.354, 0.695, P <0.05 or P <0.01). Multiple regression analysis showed that BMI, WHR, HbA_1c and HOMA-IR were independent risk factors affecting serum A-FABP (t = 2.621,4.461,7.362,3.875, P <0.05). Conclusion A-FABP is closely related to IR. With the increase of IR, the level of A-FABP gradually increases.