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采用溶液法合成了一种新型铜(Ⅱ)配合物[Cu2(NO3)2L(phen)2(H2O)]NO3(HL=2-苯基-4-硒唑甲酸,phen=1,10-邻菲啰啉)。用元素分析、红外光谱等表征手段确定了配合物的组成;用单晶X-射线衍射测定了配合物的晶体结构。配合物C34H24Cu2N8O12Se属于三斜晶系,空间群P1。用溴化乙锭荧光探针法研究了配合物与DNA的相互作用。分别考察了配体和配合物对五种细菌:大肠埃氏杆菌(E.coli),表皮葡萄球菌(S.epidermidis),草绿色链球菌(S.viridans),金黄色葡萄球菌(S.aureus),鲍曼不动杆菌(A.baumanii)的抗菌活性。同时也考察了配体和配合物对人类胰腺癌PANC-28细胞和人类肝癌HuH7细胞的体外增殖抑制作用。实验结果表明配合物具有良好的生物活性。
A new copper (Ⅱ) complex [Cu2 (NO3) 2L (phen) 2 (H2O)] NO3 Phenanthroline). The composition of the complex was confirmed by elemental analysis and IR spectroscopy. The crystal structure of the complex was determined by single crystal X-ray diffraction. Complex C34H24Cu2N8O12Se belongs to the triclinic system, space group P1. The interaction of the complex with DNA was studied by ethidium bromide fluorescent probe method. The effects of ligands and complexes on five kinds of bacteria, E.coli, S. epidermidis, S. viridans, S.aureus ), A. baumanii. The inhibitory effects of ligands and complexes on human pancreatic cancer PANC-28 cells and human hepatocellular carcinoma HuH7 cells in vitro were also investigated. The experimental results show that the complex has good biological activity.